Polybromo 1 anticorps (AA 1-50)

N° du produit ABIN7451294

L’anticorps Lapin Polyclonal anti-Polybromo 1 a été validé pour IP. Il convient pour détecter Polybromo 1 dans des échantillons de Humain.

Aperçu rapide pour Polybromo 1 anticorps (AA 1-50) (ABIN7451294)

Antigène: Polybromo 1 (PBRM1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Polybromo 1 est non-conjugé

Application: Immunoprecipitation (IP)

Détail du produit anti-Polybromo 1 anticorps

Épitope: AA 1-50

Fonction: Rabbit anti-PBRM1 Antibody, Affinity Purified

Homologie: Mouse

Purification: Affinity Purified

Immunogène: between AA 1 and 50

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. Use rabbit anti-PBRM1 antibody ABIN7453903.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur Polybromo 1

Antigène: Polybromo 1 (PBRM1)

Autre désignation: PBRM1

Sujet: Background: The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. PBRM1 is a component of the SWI/SNF-B (PBAF) complex. It contains six bromodomains which are defined by a 110 amino-acid module that interacts with acetylated lysine and is found in many chromatin binding proteins and histone acetyltransferases. PBRM1 has been proposed to function as a tumor suppressor protein. Recently, PBRM1 has been found to play a role in mediating cell cycle arrest in response to DNA damage via the regulation of the tumor suppressor p21.

ID gène: 55193

UniProt: Q86U86